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9 Publications visible to you, out of a total of 9
Synthea™ Novel coronavirus (COVID-19) model and synthetic data set

Abstract

Not specified

Author: Jason Walonoski, Sybil Klaus, Eldesia Granger, Dylan Hall, Andrew Gregorowicz, George Neyarapally, Abigail Watson, Jeff Eastman,

Date Published: 2nd Oct 2021

Publication Type: Journal

The dermatologist nose best: correlation of nose-picking habits and Staphylococcus aureus-related dermatologic disease.

Abstract

Not specified

Authors: M. LaCour, K. Gleghorn, J. Wilson

Date Published: 13th Nov 2020

Publication Type: Journal

A fully featured COMBINE archive of a simulation study on syncytial mitotic cycles in Drosophila embryos.

Abstract (Expand)

COMBINE archives are standardised containers for data files related to a simulation study in computational biology. This manuscript describes a fully featured archive of a previously published simulation … study, including (i) the original publication, (ii) the model, (iii) the analyses, and (iv) metadata describing the files and their origin. With the archived data at hand, it is possible to reproduce the results of the original work. The archive can be used for both, educational and research purposes. Anyone may reuse, extend and update the archive to make it a valuable resource for the scientific community.

Authors: M. Scharm, D. Waltemath

Date Published: 11th Nov 2016

Publication Type: Journal

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.

Abstract (Expand)

Cellular signal transduction is governed by multiple feedback mechanisms to elicit robust cellular decisions. The specific contributions of individual feedback regulators, however, remain unclear. Based … on extensive time-resolved data sets in primary erythroid progenitor cells, we established a dynamic pathway model to dissect the roles of the two transcriptional negative feedback regulators of the suppressor of cytokine signaling (SOCS) family, CIS and SOCS3, in JAK2/STAT5 signaling. Facilitated by the model, we calculated the STAT5 response for experimentally unobservable Epo concentrations and provide a quantitative link between cell survival and the integrated response of STAT5 in the nucleus. Model predictions show that the two feedbacks CIS and SOCS3 are most effective at different ligand concentration ranges due to their distinct inhibitory mechanisms. This divided function of dual feedback regulation enables control of STAT5 responses for Epo concentrations that can vary 1000-fold in vivo. Our modeling approach reveals dose-dependent feedback control as key property to regulate STAT5-mediated survival decisions over a broad range of ligand concentrations.

Authors: J. Bachmann, A. Raue, M. Schilling, M. E. Bohm, C. Kreutz, D. Kaschek, H. Busch, N. Gretz, W. D. Lehmann, J. Timmer, U. Klingmuller

Date Published: 19th Jul 2011

Publication Type: Journal

Traumatic brain injuries in illustrated literature: experience from a series of over 700 head injuries in the Asterix comic books.

Abstract (Expand)

BACKGROUND: The goal of the present study was to analyze the epidemiology and specific risk factors of traumatic brain injury (TBI) in the Asterix illustrated comic books. Among the illustrated literature, … TBI is a predominating injury pattern. METHODS: A retrospective analysis of TBI in all 34 Asterix comic books was performed by examining the initial neurological status and signs of TBI. Clinical data were correlated to information regarding the trauma mechanism, the sociocultural background of victims and offenders, and the circumstances of the traumata, to identify specific risk factors. RESULTS: Seven hundred and four TBIs were identified. The majority of persons involved were adult and male. The major cause of trauma was assault (98.8%). Traumata were classified to be severe in over 50% (GCS 3-8). Different neurological deficits and signs of basal skull fractures were identified. Although over half of head-injury victims had a severe initial impairment of consciousness, no case of death or permanent neurological deficit was found. The largest group of head-injured characters was constituted by Romans (63.9%), while Gauls caused nearly 90% of the TBIs. A helmet had been worn by 70.5% of victims but had been lost in the vast majority of cases (87.7%). In 83% of cases, TBIs were caused under the influence of a doping agent called "the magic potion". CONCLUSIONS: Although over half of patients had an initially severe impairment of consciousness after TBI, no permanent deficit could be found. Roman nationality, hypoglossal paresis, lost helmet, and ingestion of the magic potion were significantly correlated with severe initial impairment of consciousness (p </= 0.05).

Authors: M. A. Kamp, P. Slotty, S. Sarikaya-Seiwert, H. J. Steiger, D. Hanggi

Date Published: 8th Apr 2011

Publication Type: Journal

Dynamical modeling of syncytial mitotic cycles in Drosophila embryos.

Abstract (Expand)

Immediately following fertilization, the fruit fly embryo undergoes 13 rapid, synchronous, syncytial nuclear division cycles driven by maternal genes and proteins. During these mitotic cycles, there … are barely detectable oscillations in the total level of B-type cyclins. In this paper, we propose a dynamical model for the molecular events underlying these early nuclear division cycles in Drosophila. The model distinguishes nuclear and cytoplasmic compartments of the embryo and permits exploration of a variety of rules for protein transport between the compartments. Numerical simulations reproduce the main features of wild-type mitotic cycles: patterns of protein accumulation and degradation, lengthening of later cycles, and arrest in interphase 14. The model is consistent with mutations that introduce subtle changes in the number of mitotic cycles before interphase arrest. Bifurcation analysis of the differential equations reveals the dependence of mitotic oscillations on cycle number, and how this dependence is altered by mutations. The model can be used to predict the phenotypes of novel mutations and effective ranges of the unmeasured rate constants and transport coefficients in the proposed mechanism.

Authors: L. Calzone, D. Thieffry, J. J. Tyson, B. Novak

Date Published: 2nd Aug 2007

Publication Type: Journal

Cell division

Abstract

Not specified

Authors: Jonathan M Scholey, Ingrid Brust-Mascher, Alex Mogilner

Date Published: 2003

Publication Type: Journal

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